Research e-infrastructures are essential for advancing research in the physical and computational sciences where data and processing requirements are significant and ever-increasing. During the last decade EC has invested in planning and developing Europe-wide research e-infrastructures and platforms to increase research output via increased integration and uptake across country borders. This arrangement however can only benefit the Greek research community if the participating national research infrastructures are themselves adequate, focused and useful. This workshop will present current issues and directions in strengthening the role of national research e-infrastructures.